Mitragotri Group Publications Selected Publications
Full List of Publications 2009 104. Mitragotri S. and Lahann J. , Physical approaches to biomaterial design, Nature Mat., 8(1): 15-23 103. Mitragotri, S., In Drug Delivery, Shape Does Matter, Pharm. Res., 26(1):232-234. 102. Champion, J. A. and Mitragotri, S., Shape Induced Inhibition of Phagocytosis of Polymer Particles, Pharm. Res., 26(1):244-249. 2008 101. Arora, A., Prausnitz, M. R. and Mitragotri, S., Micro-scale devices for transdermal drug delivery, Int J Pharm., 364(2):227-236. 100. Muro, S., Garnacho, C., Champion, J. A., Leferovich, J., Gajewski, C., Schuchman, E. H., Mitragotri, S. and Muzykantov, V. R., Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers, Mol. Therapy, 16(8):1450-1458. 99. Whitehead, K., Karr, N. and Mitragotri, S., Safe and effective permeation enhancers for oral drug delivery, Pharm. Res., 25(8):1782-1788. 98. Champion, J. A., Walker, A. and Mitragotri, S., Role of particle size in phagocytosis of polymeric microspheres, Pharm. Res., 25(8):1815-1821. 97. Dinh, A. T., Pangarkar, C. and Mitragotri, S., Understand discrete nanoscale transport, Chem. Eng. Prog. 104(6):62-68. 96. Ogura, M., Paliwal, S. and Mitragotri, S., Low-frequency sonophoresis: Current status and future prospects, Adv. Drug Del. Rev. 60(10):1218-1223. 95. Whitehead, K., Karr, N. and Mitragotri, S., Discovery of synergistic permeation enhancers for oral drug delivery, J Control Release. 128(2):128-133. 94. Whitehead, K. and Mitragotri, S., Mechanistic analysis of chemical permeation enhancers for oral drug delivery, Pharm. Res., 25(6):1412-1419. 2007 93. Champion J., Katare, Y. and Mitragotri, S., Making Polymeric Micro- and Nanoparticles of Complex Shapes, PNAS, 104(29), 1901-4. 92. Chambers E, Mitragotri S., Long circulating nanoparticles via adhesion on red blood cells: mechanism and extended circulation, Exp Biol Med (Maywood). 232(7):958-66. 91. Champion JA, Katare YK, Mitragotri S., Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers, J Control Release. Apr 11. (Epub ahead of print). 90. Hall SS, Mitragotri S, Daugherty PS., Identification of peptide ligands facilitating nanoparticle attachment to erythrocytes, Biotechnol Prog. May-Jun; 23(3):749-54. 89. Arora, A., Hakin, I., Baxter, J., Rathnasingham, R., Srinivasan, R., Fletcher, D., and Mitragotri, S., Needle-free delivery of macromolecules across skin using nanoliter-volume pulsed microjets, PNAS, 104(11):4255-60. 86. Dinh T., Theofanous, T., Mitragotri, S., Modeling of pattern regulation in melanophores, J Theor Biol., 7:244(1):141-53. 85. Paliwal, S. and Mitragotri, S., Ultrasound-induced cavitation: applications in drug and gene delivery, Expert Opin Drug Deliv. 3(6):713-26. 84. Karande, P., Jain A., and Mitragotri, S., Insights into synergistic interactions in binary mixtures of chemical permeation enhancers for transdermal drug delivery.J Control Release, 115(1):85-93. 83. Baxter, J. and Mitragotri, S., Needle-free liquid jet injections: mechanisms and applications, Expert Rev Med Devices, 3(5):565-74. 82. Karande, P., Jain, A., and Mitragotri, S., Multicomponent Formulations of Chemical Penetration Enhancers: Opportunities, Methods and Applications, in Dermatological and Cosmeceutical Development, K. Walters and M. Roberts (Eds.). 81. Mitragotri, S. and Doukas, A., Pressure Waves for Enhancing Transdermal Drug Delivery, in Dermatological and Cosmeceutical Development, K. Walters and M. Roberts (Eds). 80. Mitragotri, S., Temperature-dependence of Skin Permeability to Hydrophilic and Hydrophobic Solutes, J Pharm Sci. Nov 8; [Epub ahead of print]. 79. Chambers E. and Mitragotri, S., Circulation of Polymeric Nanoparticles via Adhesion to Red Blood Cells: Mechanisms and Prolonged Circulation, in review. 78. Paliwal S, Menon GK, and Mitragotri S., Low-Frequency Sonophoresis: Ultrastructural Basis for Stratum Corneum Permeability Assessed Using Quantum Dots, J. Invest. Dermatol., 126(5):1095-101. 77. Mitragotri, S., Current Status and Future Prospects of Needle-free Liquid Injections, Nature Reviews Drug Discovery, 5(7):543-8. 76. Dinh, A-T, Pangarkar, C., Theofanous T. and Mitragotri, S., Spatial Patterns of Intracellular Organelles, Biophys J. , 15;90(10):L67-9. 75. Champion J. and Mitragotri, S., “Role of Target Geometry in Phagocytosis”, PNAS, 103(13):4930-4, 2006. 74. Karande, P., Jain, A., and Mitragotri, S., Relationships between Skin’s Electrical Impedance and Permeability in the Presence of Chemical Enhancers, J Control Release, 2006 Jan 10; 110(2):307-13. 73. Lee PJ, Ahmad N, Langer R, Mitragotri S, Prasad Shastri V. Evaluation of chemical enhancers in the transdermal delivery of lidocaine, Int J Pharm., 3;308(1-2): 33-9. 2005 72. Mitragotri, S., "Immunization without Needles", Nature Reviews Immunology, 5(12):905-16. 71. Pangarkar, C., Dinh, A-T, and Mitragotri, S., Dynamics and Spatial Distribution of Endosomes in Mammalian Cells, Phys. Rev. Lett., 95(15):158101. 70. Dinh, A-T, Theofanous, T., Mitragotri, S., A Model for Intracellular Trafficking of Adenoviral Vectors, Biophys. J., Sep;89(3):1574-88. 69. Baxter, J. and Mitragotri, S., Jet-Induced Skin Puncture and its Impact on Needle-free Jet Injections: Experimental Studies and a Predictive Model, J. Control. Rel., 106(3):361-73. 68. Mitragotri, S., Low-Frequency Sonophoresis: Ultrasound-Mediated Transdermal Drug Delivery”, Emerging Therapeutic Ultrasound, Ed. J. Wu., in press. 67. Tezel, A., Paliwal, S., Shen, Z., and Mitragotri, S. Low-Frequency Ultrasound as a Transcutaneous Vaccination Adjuvant, Vaccine, 23(29):3800-7. 66. Newsam J., King-Smith D., Jain, A. Karande, P, Feygin, I. Burbaum, J. Gowrishankar, T.R, Sergeeva, M. and Mitragotri, S. “Leveraging High Throughput Experimentation at the Materials-Biology Interface”, J. Mater. Chem., 15(30), 3061-3068 (Feature article-cover page). 65. Karande, P., Jain, A., and Mitragotri, S., Design Principles of Chemical Penetration Enhancers for Transdermal Drug Delivery, PNAS, 102(13): 4688-93 (Highlighted in Nature Reviews Drug Discovery, May 2005, JAMA 293:2083, 2005, and Nature Biotechnology, 23: 437, 2005). 64. Mitragotri, S., Healing Sound: the Use of Ultrasound in Drug Delivery and Other Therapeutic Applications, Nature Reviews Drug Discovery, 4(3): 255-60. 63. Paliwal, S., Sundaram, J., and Mitragotri, S., Induction of Specific Cytotoxicity towards Human Prostate and Skin Cancer Cells using Quercetin and Ultrasound, Br. J. Cancer, 92(3):499-502. 2004 62. Jain, A.K., Karande, P. and Mitragotri, S., High Throughput Screening of Chemical Enhancers: Opportunities, Methods, and Applications, In Penetration Enhancers, Eds. Smith, E. and Maibach, H., CRC Press, in press. 61. Mitragotri, S., Transdermal Drug Delivery using Low-Frequency Sonophoresis, In Encyclopedia on BioMEMS and Biomedical Nanotechnology, Bhatia, S. and Desai, T.A, in press. 60. Jain, A.K., Karande, P. and Mitragotri, S., Skin Impedance Guided High Throughput Screening of Penetration Enhancers, In Percutaneous Absorption, Eds. Bronaugh, R.L. and Maibach, H., Marcel Dekker, in press. 59. Karande, P., Jain, A.K., and Mitragotri, S., Synergistic Combinations of Penetration Enhancers and their Discovery using High Throughput Screening, In Pharmaceutical Excipients, Eds. Chaubal, M. and Katdare, A., in press. 58. Chambers, E., and Mitragotri, S., Prolonged Circulation of Large Polymeric Nanoparticles by Erythrocyte Adhesion, J. Control Rel. 100(1):111-9. 57. Tezel, A., Dokka, S., Mitragotri, S., Topical Delivery of Anti-sense Oligonucleotides using Low-Frequency Sonophoresis, Pharm. Res. 21(12):2219-25. 56. Whitehead, K. and Mitragotri, S., Oral Delivery of Macromolecules, Drug Delivery Companies Report, PharmaVentures, Winter/Autumn 2004. 55. Mitragotri, S., Sonophoresis: A Fifty Year Journey, Drug Discovery Today, 9(17): 735-6. 54. Whitehead, K., Shen, Z. and Mitragotri, S., Oral Delivery of Macromolecules using Intestinal Patches: Applications to Insulin Delivery, J. Control. Rel. 98(1): 37-45. 53. Schramm-Baxter, J. and Mitragotri, S., Needle-Free Jet Injections: Dependence of Jet Penetration on Jet Power, J. Control. Rel. 97(3): 527-535.. 52. Schramm-Baxter, J., Katrencik, J., and Mitragotri, S., Penetration of Liquid Jets into Polyacrylamide Gels: A Model Study for Jet Injections, J. Biomechanics 37(8): 1181-1188. 51. Karande, P. Jain, A., and Mitragotri, S., Discovery of Safe and Potent Transdermal Penetration Enhancers by High Throughput Screening, Nature Biotechnology22 (3): 192-197, 2004. Commentary in 22(3): 165-167 50. Mitragotri, S., Breaking the Skin Barrier: Technologies for Enhancing Skin Permeability, Adv. Drug Del. Rev. 56(5): 555-556, 2004. 49. Prausnitz, M., Mitragotri, S., and Langer, R., Current Status and Future Potential of Transdermal Drug Delivery, Nature Rev. Drug Discovery, 3:115-124, 2004. 48. Mitragotri, S. and Kost, J., Low-Frequency Sonophoresis, Adv. Drug Del. Rev. 56(5): 589-601. 2003 47. Lahann, J., Mitragotri, S., Tran, S., Kaido, H., Sundaram, J., Somorjai, G., and Langer, R., A Reversibly Switching Surface, Science2003, 299: 371-774Commentary in Science, 299: 321-323. 46. Sundaram, J., Mellein, B., Mitragotri, S., An Experimental and Theoretical Analysis of Cell Membrane Permeabilization Induced by Low-Frequency Ultrasound, Biophys. J., 84:1-15, 2003 45. Tezel, A. and Mitragotri, S., On the Origin of Size-Dependent Tortuosity of Permeation of Hydrophilic Solutes across Stratum Corneum, J. Control. Rel. 86:1, 183-186, 2003. 44. Tezel, A. and Mitragotri, S., Interactions of Cavitation Bubbles with the Stratum Corneum during Low-Frequency Sonophoresis, Biophys. J. 85:1-11, 2003 43. Karande, P. and Mitragotri, S., Dependence of Skin Permeability on Contact Area, Pharm. Res. 20 (2): 254-260, 2003. 42. Mitragotri, S., Modeling Passive Skin Permeability to Hydrophilic and Hydrophobic Solutes based on Four Permeation Pathways, J. Control. Rel. 86 (1): 69-92, 2003. 41. Tezel, A., Sens, A., and Mitragotri, S., Description of Transdermal Transport of Hydrophilic Solutes during Low Frequency Sonophoresis Based on a Modified Porous Pathway Model, J. Pharm. Sci.92:1, 381-393, 2003. 40. Mitragotri, S. and Kost, J., Ultrasound-Mediated Transdermal Drug Delivery, Modified-Release Drug Delivery Technology, Rathbone, Hadgraft, Roberts (Eds.), 561-570, chapter 46, 2003. 2002 39. Schramm, J. and Mitragotri, S., A Fundamental Investigation of Drug Delivery using Jet Injectors: Energetics of Jet Formation and Penetration, Pharm. Res., 19:11, 1673-1679, 2002. 38. Tezel, A., Sens, A., and Mitragotri, S., A Theoretical Analysis of Low-Frequency Sonophoresis: Dependence of Transdermal Transport Pathways on Frequency and Energy Density, Pharm. Res. 19:12, 1841-1846, 2002. 37. Tezel, A., Sens, A., and Mitragotri, S., Incorporation of Lipophilic Pathways into the Porous Pathway Model to Describe Transdermal Transport during Low- Frequency Sonophoresis, J. Control. Rel.83:1, 183-188, 2002. 36. Karande, P. and Mitragotri, S., High Throughput Screening of Transdermal Enhancer Formulations, Pharm. Res., 19(5): 655-660, 2002 35. Shen, Z. and Mitragotri, S., Intestinal Patches for Oral Drug Delivery, Pharm. Res., 19(4): 391-395, 2002. 34. Mitragotri, S., A Theoretical Analysis of Permeation of Small Hydrophobic Solutes across the Skin based on Scaled Particle Theory, J. Pharm. Sci., 91:754-757, 2002. 33. Terahara, T., Mitragotri, S., Kost, J., Langer, R., Dependence of Low-Frequency Sonophoresis on Ultrasound Parameters: Distance of the Horn and Intensity, Int. J. Pharm., 235:35-42, 2002. 32. Terahara, T., Mitragotri, S., Langer, R., Porous Resins as a Cavitation Enhancer for Low Frequency Sonophoresis, J. Pharm. Sci., 91:753-759, 2002. 31. Investigations of Role of Cavitation in Low-Frequency Sonophoresis using Acoustic Spectroscopy", Tezel, A., Sens, A., Mitragotri, S., J. Pharm. Sci., 91:444-453, 2002 2001 30. Mitragotri, S., Effect of Bilayer Disrupting Agents on Skin Permeability to Low-Molecular Weight Hydrophobic Drugs, Pharm. Res., 18:1022-1028, 2001. 29. Kost, J., Mitragotri, S., Langer, R., Phonophoresis, Topical Absorption of Dermatological Products, 335-351, 2001. 28. Mitragotri, S. and Kost, Transdermal Delivery of Heparin and Low-Molecular Weight Heparin using Low-Frequency Ultrasound, Pharm. Res., 18:1022-1027, 2001. 27. Tezel, A., Sens, A., Tuscherer, J., Mitragotri, S., Synergistic Effect of Surfactants and Low-Frequency Ultrasound on Skin Permeability, J. Pharm. Sci., 91:1, 91-100, 2001. 26. Tezel, A., Sanders, A., Tuscherer, J., Mitragotri S., Frequency-dependence of Sonophoresis, Pharm. Res., 18:12, 1694-1700, 2001. 2000 25. Tang, H., Mitragotri, S., Blankschtein, D., Langer, R., Theoretical Description of Transdermal Transport of Hydrophilic Permeants: Application to Low-Frequency Sonophoresis, J. Pharm. Sci., 90:543-566, 2000. 24. Kost, J., Mitragotri, S., Gabbay, B., Pishko, M., Langer, R., Transdermal Monitoring of Glucose and Other Analytes Using Ultrasound, Nature Medicine, 6:347-350, 2000. 23. Mitragotri, S., Farrell, J., Tang, H., Terahara, T., Kost, J., Langer, R., Determination of the Threshold Energy Dose for Ultrasound-Induced Transdermal Drug Delivery, J. Control Rel., 63:41-52, 2000. 22. Mitragotri, S., Ray, D., Farrell, J., Tang, H., Yu, B., Kost, J., Blankschtein, D., Langer, R., Synergistic Effect of Low-Frequency Ultrasound and Sodium Lauryl Sulfate on Transdermal Transport, J. Pharm. Sci., 89:892-900, 2000. 21. Mitragotri, S., Kost, J., Langer, R., Enhancement of Transdermal Transport Using Ultrasound in Combination with Other Enhancers, Handbook of Pharmaceutical Controlled Release Technology, Wise, D. (Ed.), pp. 607-616 20. Mitragotri, S., Coleman, M., Kost, J., Langer, R., Transdermal Extraction of Analytes using Low-Frequency Ultrasound, Pharm. Res., 17(4): 467-470, 2000. 19. Mitragotri, S., Coleman, M., Kost, J., Langer, R., Analysis of Ultrasonically Extracted Interstitial Fluid as a Predictor of Blood Glucose Levels, J. Appl. Physiol., 89:961-966, 2000. 18. Mitragotri, S., Kost, J., Low-Frequency Sonophoresis: A non-Invasive Method for Drug Delivery and Diagnostics, Biotechnology Progress, 16(3):488-492, 2000. 17. Mitragotri, S., Kost, J., Langer, R., Non-Invasive Drug Delivery and Diagnostics Using Low-Frequency Sonophoresis, Recent Advances and Research Updates, 1:41-48., 2000. 16. Mitragotri, S., In Situ Determination of Partition and Diffusion Coefficients in the Lipid Bilayers of the Stratum Corneum, Pharm. Res., 17(8):1024-1027, 2000. 15. Le, L., Kost, J., Mitragotri, S., Combined Effect of Low-Frequency Ultrasound and Iontophoresis: Applications for Transdermal Heparin Delivery, Pharm. Res., 17:1354-1557, 2000. 14. Mitragotri, S., Synergistic Effect Enhancers on Transdermal Drug Delivery, Pharm. Res., 17:11:1354-1359, 2000. 13. Tang, H., Mitragotri, S., Blankschtein, D., Langer, R., Enhancement of Transdermal Drug Transport by Ultrasound: Sonophoresis", Encl. of Pharm. Tech., Swarbrick, J., Boylan, J., 2000. 12. Mitragotri, S , Effect of Therapeutic Ultrasound on Partition and Diffusion Coefficients in the Lipid Bilayers of Stratum Corneum, J. Control. Rel., 71:23-29, 2000. 1995-1999 11. Kost, J., Mitragotri, S., Langer, R., Phonophoresis, Percutaneous Absorption, Bronaugh, R., Maibach, H.I., (Eds.), pp. 615-631., 1999. 10. Mitragotri, S., Johnson, M., Blankschtein, D., Langer, R., An Analysis of the Size Selectivity of Solute Partitioning, Diffusion, and Permeation across Lipid Bilayer Systems, Biophys. J., 77:1268-1283, 1999. 9. Mitragotri, S., Langer, R., Kost, J., Ultrasound for Modulation of Skin Transport Properties, Biomaterials Engineering and Devices: Human Applications, Wise, D. (Ed.), pages 843-854, 1999. 8. Mitragotri, S., Blankschtein, D., Langer, R., An Explanation for the Variation of the Sonophoretic Transdermal Transport Enhancement from Drug to Drug, J. Pharm. Sci., 86:10, 1190-92, 1997. 7. Constantino, R., Liauw, S., Mitragotri, S., Klibanov, A., Langer, R., Sluzky, V., Pharmaceutical Developments of Insulin, In “Therapeutic Protein and Peptide Formulation and Delivery", ACS Symposium, Shahrokh, Z., Sluzky, V., Cleland, J., Shrine, S., Randolph, T. (Eds.), 29-66.¸1997. 6. Kost, J., Pliquett, U., Mitragotri, S., Yamamoto, A., Langer, R., Weaver, J., Synergistic Effect of Electric Field and Ultrasound on Transdermal Transport, Pharm. Res., 13:4, 633-638¸1996. 5. Mitragotri, S., Blankschtein, D., Langer, R., Transdermal Drug Delivery Using Low-Frequency Sonophoresis, Pharm. Res., 13:3, 411-420, 1996. 4. Mitragotri S., Blankschtein D., Langer, R., Sonophoresis: Enhanced Transdermal Drug Delivery by Application of Ultrasound, Encl. of Pharm. Tech., vol. 14, Swarbrick, J., Boylan, J., (Eds.), vol. 14, 103-122, 1996. 3. Johnson, M.E., Mitragotri, S., Patel, A., Blankschtein, D., Langer, R,, Synergistic Effects of Chemical Enhancers and Therapeutic Ultrasound on Transdermal Drug Delivery, J. Pharm. Sci., 85:7, 670-679¸1996. 2. Mitragotri, S., Blankschtein, D., Langer, R., Ultrasound-Mediated Transdermal Protein Delivery, Science, 269: 850-853, 1995. 1. Mitragotri, S., Edwards, D., Blankschtein, D., Langer, R., A Mechanistic Study of Ultrasonically-Enhanced Transdermal Drug Delivery, J. Pharm. Sci., 84: 697-706, 1995. |